By Yunkyu Sohn
Bonifazi et al. introduces the first direct evidence for the presence of pace makers (functional hubs) in the neuro-synaptic level network of Hippocampus. They developed a novel method to construct functional connectivity matrix in real time in living brain slices. Through the dynamic analysis of this network they found out that there exists role-differentiation of the neurons for the synfire activity of the overall network: High Connectivity pace maker neurons and Low Connectivity follower neurons.